Wydanie 1/2019
str. 74 - 77

Wpływ doustnego stosowania kwasu alfa-liponowego, witamin B1 i B2 oraz rutozydu na zmiany morfologiczne i funkcjonalne siatkówki u chorych na retinopatię cukrzycową

The Impact of Oral Application of Alpha-lipoic Acid, Vitamins B1 and B2 and Rutoside on the Morphological and Functional Retinal Changes in Patients with Diabetic Retinopathy

Małgorzata Mulak 1 , Maciej Osęka 2 , Maria Sobol 3

1 Katedra i Klinika Okulistyki we Wrocławiu
Kierownik: prof. dr hab. n. med. Marta Misiuk-Hojło
2 Oftalabs Sp. z o.o.
3 Zakład Biofizyki i Fizjologii Człowieka Warszawskiego Uniwersytetu Medycznego
Kierownik: prof. dr hab. n. med. Jacek Przybylski

Summary: More and more people around the world are being diagnosed with diabetes, which leads to systemic complications, including ophthalmological ones. That, in turn, causes significant health and economic problems for both individuals and national budgets. Standard diabetes treatment includes laser therapy, intravitreal injections and surgery, though more and more attention is also being paid to diabetic retinopathy prevention. Alpha-lipoic acid, vitamins B1 and B2 and rutoside are mentioned among possibly protective substances. Alpha-lipoic acid is an eight-carbon saturated fatty acid that dissolves in water and fats and, in addition to multiple other valuable properties, increases insulin sensitivity as well as normalises sugar levels in the blood, whereas vitamins B1 and B2 and rutoside influence the diabetic metabolic processes.
The aim of the study was to examine the effect of a 6-month oral application of alpha-lipoic acid, vitamins B1 and B2 and rutoside on the functional and morphological ophthalmological parameters in patients with diabetes. 32 individuals (22 women and 10 men) were included in the study, out of whom 3 suffered from type 1 diabetes, while the rest had type 2 diabetes. The average duration of diabetes was 12.7 years. Patients were examined during three visits: the preliminary one and then after three and six months. The best corrected visual acuity test, ophthalmoscopy, an intraocular pressure test, a visual field examination (using the Humphrey perimeter) and an optical coherence tomography test were all performed. Besides, a colour fundus photograph was taken at each visit. 25 patients (50 eyes) who had attended all the control visits were included for the final analysis. Individuals who had missed any of the checks or those who had undergone cataract surgery in the meantime had been excluded. During observation, a statistically significant increase in visual acuity and a retinal thickness reduction in the optical coherence tomography examination were stated. The visual field parameters and the intraocular pressure values had not changed. In most cases, the medication was well tolerated. The test results are not unambiguous, but they encourage further testing using different measurement methods and active substances dosing patterns.

Słowa kluczowe: cukrzyca, retinopatia cukrzycowa, kwas alfa-liponowy.

Keywords: diabetes, diabetes retinopathy, alpha-lipoic acid.