Wydanie 3/2010
str. 71

Leczenie farmakologiczne ocznej postaci toksokarozy

Pharmacological Therapy of Ocular Toxocarosis

Agnieszka Moll, Małgorzata Budzińska-Mikurenda, Anna Niwald

Klinika Okulistyki Dziecięcej Katedry Pediatrii Zabiegowej Uniwersytetu Medycznego w Łodzi
Samodzielny Publiczny Zakład Opieki Zdrowotnej Uniwersyteckiego Szpitala Klinicznego nr 4 Uniwersytetu Medycznego w Łodzi
Kierownik: dr hab. n. med. Anna Niwald

Summary: Toxocarosis is a common zoonosis, especially in children. Its’ clinical course can be asymptomatic or can take some recognizable forms with particular signs and symptoms like positive serology, diagnosed and confirmed by enzyme-linked immunosorbent assay testing, eosinophilia and increased IgE levels. Ocular toxocarosis is a localized manifestation of Toxocara infection, from localized peripheral or macular granulomas to chronic endophthalmitis, and may cause progressive ocular damage leading to visual loss. The diagnosis of ocular toxocarosis is difficult, mostly in atypical cases, in which comparative immunological profiles of intraocular fluid and serum samples analysis can be helpful. Treatment of this disease can be challenging. Specific pharmacological anthelminthic therapy is based on two groups of drugs. One is benzimidazole derivatives such as: albendazole, mebedazole and thiabendazole and the other includes diethylcarbamazine. The recommended dose of albendazole is 15 mg/ kg body weight daily for 5 days and diethylcarbamazine 6 mg/ kg body weight daily for 10 days. Anthelminthic treatment is associated with inflammatory reactions due to parasite lysis. Corticosteroids and other anti-inflammatory drugs should be administered simultaneously to limit tissue damage. Sometimes therapy should be repeated according to clinical improvement and laboratory findings. Early and correct diagnosis and competent treatment of ocular toxocarosis is essential to prevent permanent visual loss.

Słowa kluczowe: toksokara, toksokaroza oczna, farmakoterapia, albendazol, mebendazol, tiabendazol, dietylkarbamazyna.

Keywords: toxocara, ocular toxocarosis, pharmacotherapy, albendazole, mebendazole, thiabendazole, diethylcarbamazine.