Wydanie 3/2007

Zagadnienie neuroprotekcji w jaskrze

Neuroroprotection Issues in Glaucoma

Magdalena Pilas-Pomykalska, Janusz Czajkowski

Klinika Okulistyki Instytutu "Centrum Zdrowia Matki Polki" w Łodzi Kierownik: prof. dr hab. n. med. Janusz Czajkowski


Summary: Glaucoma is a neurodegenerative disease with multifactorial pathogenesis, which leads to progressive retinal ganglion cells death. Current therapeutic strategies are focused on the reduction of the elevated IOP. Neuroprotection is a new destination in glaucoma therapy. The aim of neuroprotection is to protect the RGCs from early death due to endotoxins, exotoxins or ischaemia. Neuroprotection works by preventing RGCs from dying and keeping them in a functional state. The goal can be achieved by enhancing survival-signaling pathways or inhibiting death-signaling pathways. Recently dozens of potentially neuroprotective agents have been recognized. The aim of the paper is to discus the term of neuroprotection in glaucoma, and currently most promising agents and medications with potential neuroprotective properties.

Keywords: neuroprotection, glaucoma.


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