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Wydanie 4/2008
str. 66

Skuteczność i bezpieczeństwo ofloksacyny w leczeniu bakteryjnych zapaleń oka - przegląd piśmiennictwa

Review of the Efficacy and Safety of Ofloxacin for the Treatment of Ocular Infections

Charles Slonim, Jacek P. Szaflik

Department of Ophthalmology, University of South Florida College of Medicine, Tampa, FL (USA)
Katedra i Klinika Okulistyki II Wydziału Lekarskiego Warszawskiego Uniwersytetu Medycznego Samodzielny Publiczny Kliniczny Szpital Okulistyczny w Warszawie Kierownik: prof. dr hab. n. med. Jerzy Szaflik

Summary: Common external bacterial infections of the eye, including blepharitis, conjunctivitis, and keratitis (e.g., corneal ulcers) can be successfully treated with administration of a topical ophthalmic antibiotic effective against gram-positive and gram-negative pathogens. The introduction of topical ophthalmic fluoroquinolone antibiotics provided the first class of antibiotics that are highly effective against Pseudomonas and Staphylococcus species without the need of fortification for the treatment of bacterial keratitis. Topical ophthalmic fluoroquinolone antibiotics are safer than fortified antibiotics. Ofloxacin 0.3% ophthalmic solution has demonstrated efficacy and safety in the treatment of bacterial conjunctivitis and bacterial keratitis. It penetrates the cornea and is effective when used as prophylaxis for cataract surgery. Despite some reports of in vitro resistance, most common ocular pathogens remain clinically susceptible to ofloxacin 0,3%. Topical administration of ofloxacin 0,3% is equally well tolerated as lubricant eye drops. It rarely causes systemic adverse effects, and it is rarely is associated with adverse effects on visual acuity, ophthalmoscopic findings, or lens pathology.

Keywords: ofloksacyna, bakteryjne zapalenia oka, skuteczność, bezpieczeństwo.

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