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Wydanie 2/2004

Wartość diagnostyczna poziomów VEGF i PEDF dla oceny procesu neowaskularyzacyjnego w chorobach oczu

Diagnostic value of VEGF and PEDF for evaluation of neovascular process in ocular diseases

Jerzy Z. Nowak

Zakład Farmakologii Uniwersytetu Medycznego w Łodzi Kierownik: prof. dr hab. Jerzy Z. Nowak

Summary: An array of ocular diseases result from (or are accompanied by) neovascularization. They include, among others, retinopathy of prematurity, diabetic retinopathy or age-related macular degemneration. The process of neovascularization is developing under condition of a functional dominance of proangiogenic factors over antiangiogenic ones. Vascular endothelial growth factor (VEGF) is a key stimulator of angiogenesis, while a recently discovered pigment epithelium-derived factor (PEDF) appears to be a powerful endogenous inhibitor of angiogenesis. This paper reviews recent ?human? experimental findings showing ocular levels/concentrations of VEGF and PEDF in various ophthalmological diseases occurring with neovascularization. Based on literature experimental and clinical data, a possible diagnostic/prognostic value of increased and/or decreased concentrations of ocular VEGF and PEDF, respectively, is discussed in terms of both development of a given disease and effectiveness of a given therapeutic approach.

Keywords: neovascularization, VEGF (vascular endothelial growth factor), PEDF (pigment epithelium-derived factor), ocular diseases.

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