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Wydanie 3/2007

Rola zaburzeń hemodynamicznych krążenia naczyniówkowego w etiopatogenezie zwyrodnienia plamki związanego z wiekiem

Choroidal Perfusion Haemodynamic Abnormalities Role in Age-Related Macular Degeneration (AMD) Pathogenesis

Agnieszka Kubicka-Trząska

Klinika Okulistyki i Onkologii Okulistycznej Katedry Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie Kierownik: dr hab. n. med. Bożena Romanowska-Dixon

Summary: Age-related macular degeneration (AMD) is a disease characterized by the presence of functional and morphological alterations in the retina, Bruch?s membrane, retinal pigment epithelium, choriocapillares and larger choroidal vessels in addition to ocular perfusion changes. In patients with early stage of AMD, with age-related maculopathy (ARM) many various vascular alterations have been reported: increased number of ischemic retinal capillaries and obliteration of choriocapillares, delayed choroidal vessels filling, choroidal blood flow reduction, increase in pulsatility and decreased velocity of the short posterior ciliary arteries and central retinal artery. It is supposed that instead of primary RPE dysfunction and genetic factors, alteration in choroidal haemodynamics may play an important role in AMD pathogenesis. The aim of this paper is to review the current knowledge about the local circulatory abnormalities in patients with AMD.

Keywords: age-related macular degeneration, pathogenesis, choroidal perfusion

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